. Form liquid
\n. Alternative Name AGER, RAGE
\n. Purification protein A+G purified
\n. Purity 95% as determined by SDS-PAGE
\n. Host Mouse
\n. Isotype IgG1
\n. Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze \/ thaw cycles.)
\n. Background\/ FUNCTION
\n. Mediates interactions of advanced glycosylation end products(AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE\/RAGE signaling plays an important role in regulating the production\/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1\/2 and p53\/TP53 signaling(By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide(ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase(MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.
\n. Immunogen advanced glycosylation end product-specific receptor
\n. Specificity Human, Rat
\n. Tested Application ELISA, WB
\n. Recommended dilution WB: 1:1000-1:5000
\n. IHC use
\n. WB use
\n. Rar lung tissue were subjected to SDS PAGE followed by western blot with PAab09951(AGER Antibody) at dilution of 1:2000
\n. Protein Information
\n. Gene ID 177
\n. Uniprot ID Q15109
\n. Calculated MW 43 kDa
\n. Research Area Immunology, Signal Transduction, Developmental biology<\/p>\n","protected":false},"excerpt":{"rendered":"
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