ANCA Pro is a solid phase enzyme immunoassay employing highly purified native myeloperoxidase (MPO) and proteinase 3 (PR3) from human peripheral blood polymorphnuclear cells and native human Cathepsin G, Elastase, Lactoferrin, Lysozym and BPI (bacterial permeability-increasing protein) for the separate semi-quantitative and qualitative detection of antibodies against these antigens in human serum. The assay is a tool in the diagnosis of autoimmune systemic vasculitis.
PR3 sensitive is a solid phase enzyme immunoassay employing highly purified native human proteinase 3 (PR3) from human neutrophil granulocytes for the quantitative detection of antibodies against proteinase 3 in human serum. Anti-PR3 antibodies recognize specificially conformational epitopes only accessible on native PR3. The assay is an aid in the differential diagnosis of autoimmune vasculitis
MPO is a solid phase enzyme immunoassay employing highly purified native myeloperoxidase (MPO) from human peripheral blood polymorphnuclear cells for the quantitative detection of antibodies against MPO in human serum. Anti-MPO antibodies recognize specific conformational epitopes only accessible on native MPO. The assay is a tool in the differential diagnosis of autoimmune systemic vasculitis.
BPI is a solid phase enzyme immunoassay employing highly purified native human BPI (bactericidal/permeability-increasing protein) for the quantitative detection of antibodies against BPI in human serum. Antibodies against BPI can be found in chronically infectious intestinal diseases such as Morbus Crohn or ulcerative colitis.
Elastase is a solid phase enzyme immunoassay employing native human Elastase for the quantitative detection of antibodies against Elastase in human serum. The assay is a tool in the diagnosis of autoimmune systemic vasculitis.
Lactoferrin is a solid phase enzyme immunoassay with human native nucleosomes isolated from the eukaryotic celline HeLa for the quantitative detection of antibodies against nucleosomes and their components dsDNA and histones in human serum. The assay is a tool in the differential diagnosis of systemic lupus erythematosus (SLE).
GBM is a solid phase enzyme immunoassay employing recombinant human glomerular basement membrane protein (GBM) for the quantitative detection of IgG antibodies against GBM in human serum. The assay is an aid in the diagnosis of Goodpasture syndrome.
Vasculitis-Screen is a solid phase enzyme immunoassay for the combined quantitative detection of antibodies against PR3 and MPO in human serum. Each well is coated with native human proteinase 3 (PR3) plus native myeloperoxidase (MPO), both highly purified from human peripheral blood polymorphnuclear cells. Anti-PR3 and anti-MPO antibodies recognize specificially conformational epitopes only accessible on the native target antigen. The assay is an aid in the differential diagnosis of autoimmune vasculitis.