Description

. Form liquid
. Alternative Name ABC29; ABCC; ABCC1; ATP-binding cassette sub-family C member 1; ATP-binding cassette, sub-family C(CFTR/MRP), member 1; EC 3.6.3; EC 3.6.3.44; GS-X; Leukotriene C(4) transporter; LTC4 transporter; MRP1;multidrug resistance associated protein 1; multidrug resistance protein; multidrug resistance-associated protein 1; multiple drug resistance protein 1; multiple drug resistance-associated protein
. Purification Immunogen affinity purified
. Purity 95% as determined by SDS-PAGE
. Host Rabbit
. Isotype IgG
. Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
. Background/ FUNCTION
. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette(ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies(ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts.
. Immunogen ABCC1
. Specificity Human, Mouse, Rat
. Tested Application ELISA, IHC, WB
. Recommended dilution WB 1:500-1:1000; IHC 1:50-1:100
. IHC use Immunohistochemistry of paraffin-embedded Human lung cancer tissue using PAab09806(ABCC1 antibody) at dilution of 1:50
. WB use
. A549 cell lysate were subjected to SDS PAGE followed by western blot with PAab09806(ABCC1 antibody) at dilution of 1:500
. Protein Information
. Gene ID
. Uniprot ID P33527
. Calculated MW
. Research Area