Description

. Form liquid
. Alternative Name ARHGEF1, GEF1, LBCL2, LSC, P115 RHOGEF, p115RhoGEF, SUB1.5, ARHG1
. Purification Immunogen affinity purified
. Purity 95% as determined by SDS-PAGE
. Host Rabbit
. Isotype IgG
. Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
. Background/ FUNCTION
. Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12(GNA12) and alpha-13(GNA13) subunits. Acts as GTPase-activating protein(GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor(GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.
. Immunogen Rho guanine nucleotide exchange factor(GEF) 1
. Specificity Human, Rat
. Tested Application ELISA, IHC
. Recommended dilution IHC: 1:20-1:200
. IHC use Immunohistochemistry of paraffin-embedded rat lung using PAab10091(PER2 antibody) at dilution of 1:50
. WB use
. Protein Information
. Gene ID 9138
. Uniprot ID Q92888
. Calculated MW 102-110 kDa
. Research Area Signal Transduction, Metabolism