Description

. Form liquid
. Alternative Name AGER, RAGE
. Purification protein A+G purified
. Purity 95% as determined by SDS-PAGE
. Host Mouse
. Isotype IgG1
. Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
. Background/ FUNCTION
. Mediates interactions of advanced glycosylation end products(AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling(By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide(ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase(MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.
. Immunogen advanced glycosylation end product-specific receptor
. Specificity Human, Rat
. Tested Application ELISA, WB
. Recommended dilution WB: 1:1000-1:5000
. IHC use
. WB use
. Rar lung tissue were subjected to SDS PAGE followed by western blot with PAab09951(AGER Antibody) at dilution of 1:2000
. Protein Information
. Gene ID 177
. Uniprot ID Q15109
. Calculated MW 43 kDa
. Research Area Immunology, Signal Transduction, Developmental biology