Description

. Form liquid
. Alternative Name ATP2B, DAR, DD, SERCA2
. Purification Immunogen affinity purified
. Purity 95% as determined by SDS-PAGE
. Host Rabbit
. Isotype IgG
. Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
. Background/ FUNCTION
. This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms.
. Immunogen ATP2A2
. Specificity Human, Mouse, Rat
. Tested Application ELISA, WB, IHC, IF
. Recommended dilution WB: 1:500 – 1:2000; IHC: 1:50 – 1:200; IF: 1:50 – 1:100
. IHC use Immunohistochemistry of paraffin-embedded mouse brain using PAab09918(ATP2A2 antibody) at dilution of 1:100
. WB use
. MCF7 cells were subjected to SDS PAGE followed by western blot with PAab09918(ATP2A2 Antibody) at dilution of 1:1000
. Protein Information
. Gene ID 488
. Uniprot ID P16615
. Calculated MW 110 kDa
. Research Area