Description

. Form liquid
. Alternative Name AIF 1, AIF1, G1, IBA1, IRT 1, Protein G1
. Purification Immunogen affinity purified
. Purity 95% as determined by SDS-PAGE
. Host Rabbit
. Isotype IgG
. Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
. Background/ FUNCTION
. AIF1, also named as G1, IBA1 or daintain/AIF-1, is a 143 amino acid cytoplasmic, inflammation response scaffold protein. It is constitutively expressed in monocytes and macrophages and is known to be involved in macrophage activation. It is a marker of activated macrophage. Despite a lack of detailed knowledge on the in vivo physiological functions of AIF-1, there is growing evidence that shows its aberrant expression contributes to the pathogenesis of many autoimmune diseases, including rheumatoid arthritis. (20944424). AIF1 is an actin-binding protein that enhances membrane ruffling and RAC activation. It enhances lymphocyte migration and the actin-bundling activity of LCP1. AIF1 plays a role in RAC signaling and in phagocytosis and a role in vascular inflammation. AIF1 promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. It is also as a microglial cell marker.
. Immunogen allograft inflammatory factor 1
. Specificity Human, Mouse, Rat
. Tested Application ELISA, WB
. Recommended dilution WB: 1:500-1:2000
. IHC use
. WB use
. U937 cells were subjected to SDS PAGE followed by western blot with PAab09944(AIF1 antibody) at dilution of 1:1000
. Protein Information
. Gene ID 199
. Uniprot ID P55008
. Calculated MW 16 kDa
. Research Area Signal Transduction, Metabolism, Cardiovascular, Developmental biology, Neuroscience, Stem Cells, Immunology