Description

. Form liquid
. Alternative Name Alpha synuclein, NACP, PARK1, PARK4, SNCA
. Purification protein A+G purified
. Purity 95% as determined by SDS-PAGE
. Host Mouse
. Isotype IgG1
. Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
. Background/ FUNCTION
. Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer’s disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene.
. Immunogen synuclein, alpha (non A4 component of amyloid precursor)
. Specificity Human, Mouse, Rat
. Tested Application ELISA, IHC, WB
. Recommended dilution WB: 1:500 – 1:2000; IHC: 1:500 – 1:2000
. IHC use Immunohistochemistry of paraffin-embedded mouse brain using PAab09891(SNCA antibody) at dilution of 1:1000
. WB use
. mouse brain tissue were subjected to SDS PAGE followed by western blot with PAab09891(SNCA antibody) at dilution of 1:1000
. Protein Information
. Gene ID 6622
. Uniprot ID P37840
. Calculated MW 23 kDa
. Research Area Neuroscience