Autoimmune liver diseases include primary biliary cirrhosis (PBC), autoimmune hepatitis (AIH) and primary sclerosing cholangitis (PSC).
In autoimmune hepatitis (AIH), chronic inflammation damages liver cells. In PBC and PSC, the intrahepatic small bile ducts and large bile ducts, respectively, are attacked by the patient’s own immune system.
The Autoimmune Liver Diseases Panel offers a range of ELISA tests including anti-nuclear antibodies, anti-mitochondrial antibodies, anti-liver/kidney microsomal antibodies and anti-soluble liver antigen/liver pancreas antigen (SLA/LP) antibodies.
ANA-8S is a solid phase enzyme immunoassay for the combined qualitative detection of IgG antibodies against eight cellular and nuclear antigens in human serum. Each well is coated with recombinant 70 kDa U1-snRNP, SS-B, SS-A 52 kDa, Scl 70, centromere protein B (CenpB), Jo-1 and highly purified native human snRNP/Sm, Sm and SS-A 60 kDa. The assay is a tool in the differential diagnosis of systemic rheumatic diseases
ANA-8Pro is a solid phase enzyme immunoassay for the separate qualitative detection of IgG antibodies against eight cellular and nuclear antigens in human serum. The wells are separately coated with recombinant 70 kDa U1 snRNP, SS-B, SS-A 52 kDa, Scl 70, centromere protein B (CenpB), Jo-1 and highly purified native human snRNP/Sm, Sm and SS-A 60 kDa. The assay is a tool in the differential diagnosis of systemic rheumatic diseases.
ENA-6S is a solid phase enzyme immunoassay for the combined qualitative detection of IgG antibodies against six cellular and nuclear antigens in human serum. Each well is coated with recombinant SS-B, SS-A 52 kDa, Scl 70, Jo-1 and highly purified native human snRNP/Sm, Sm and SS-A 60 kDa. The assay is a tool in the differential diagnosis of systemic rheumatic diseases
ENA-6Pro is a solid phase enzyme immunoassay for the separate semi-quantitative detection of IgG antibodies against six cellular and nuclear antigens in human serum. The wells are coated with recombinant SS-B, SS-A 52 kDa, Scl 70, Jo-1 and highly purified native human snRNP/Sm, Sm and SS-A 60 kDa. The assay is a tool in the differential diagnosis of systemic rheumatic diseases.
U1-70 is a solid phase enzyme immunoassay employing recombinant human 70 kDa protein of the U1-snRNP complex for the quantitative detection of antibodies against the 70 kDa U1-RNP in human serum. The assay is a tool in the diagnosis of mixed connective tissue diseases (MCTD) and systemic lupus erythematosus (SLE).
snRNP-C is a solid phase enzyme immunoassay for the quantitative detection of antibodies against the snRNP complex in human serum. The assay employs native human U1-snRNP complex highly purified from the cell-line HeLa. The U1-snRNP complex comprises the Smith antigen (Sm) and RNPs, the 70kDa U1-specific protein plus protein A and C. The assay is a tool for the diagnosis of mixed connective tissue diseases (MCTD) and systemic lupus erythematosus (SLE)
Sm is a solid phase enzyme immunoassay with highly purified native Smith antigen (Sm) from human eukaryotic cells (HeLa) for the quantitative detection of antibodies against Sm in human serum. Anti-Sm antibodies recognize specific conformational epitopes only accessible on native human Sm. The assay is a tool in the differential diagnosis of systemic lupus erythematosus (SLE).
SS-A is a solid phase enzyme immunoassay for the quantitative detection of antibodies against Ro/ SS-A in human serum. The assay employs human Ro/SS-A antigen composed of highly purified native 60kDa and recombinant human 52 kDa Ro/SS-A protein. Anti-SS-A antibodies are species-specific (directed against human protein only) and preferentially react with the native 60kDa molecule where as most antibodies to the 52 kDa protein prefer the denatured molecule. The assay is a tool in the diagnosis of Sjögren`s syndrome (SS) and systemic lupus erythematosus (SLE).
SS-B is a solid phase enzyme immunoassay employing human recombinant La-antigen/ SS-B for the quantitative detection of antibodies against La-antigen / SS-B in human serum. The assay is a tool in the diagnosis of Sjögren`s syndrome (SS) and systemic lupus erythematosus (SLE).
Scl-70 is a solid phase enzyme immunoassay with human recombinant 70 kDa fragment of DNA topoisomerase I for the quantitative detection of antibodies against Scl-70 (70 kDa scleroderma antigen) in human serum. The assay is a tool in the differential diagnosis of systemic sclerosis.
Cenp-B is a solid phase enzyme immunoassay employing purified recombinant human 80 kDa centromere protein B (Cenp-B) for the quantitative and qualitative detection of IgG antibodies against Cenp-B in human serum. The assay ensures the highest specificity and sensitivity for the detection of antibodies against centromere protein B, which serves as an aid in the diagnosis of systemic sclerosis and CREST syndrome.
Jo-1 is a solid phase enzyme immunoassay with recombinant human histidyl-tRNA-synthetase (HRS) for the quantitative detection of antibodies against Jo-1 (named after the prototype patient) in human serum. Human sera with anti-Jo-1 antibodies solely recognize HRS of higher eukaryotes and react with highest affinity with the human enzyme. The assay is a tool in the diagnosis of polymyositis and dermatomyositis.
Rib-P is a solid phase enzyme immunoassay employing native human ribosomal P-proteins P0, P1 and P2 isolated from eukaryotic cell line for the quantitative detection of antibodies against ribosomal P-proteins (rib-P) in human serum. The specificity of anti-rib-P antibodies is restricted to a common antigenic determinant located on the highly conserved carboxyl-terminal portion of the three P proteins. The assay is a tool in the diagnosis of systemic lupus erythematosus (SLE).
ANA-HEp-2 is a solid phase enzyme immunoassay for the combined qualitative detection of IgG antibodies against HEp2 cells in human serum. Each well is coated with lysed HEp2 cells. The test collectively detects, in one well, total ANAs against double stranded DNA (dsDNA), histones, SS-A (Ro), SS-B (La), Sm, snRNP/Sm, Scl-70, PM-Scl, Jo-1 and centromeric antigens along with sera positive for HEp2 immunofluorescence test (IFT). The assay is a tool in the diagnosis of systemic rheumatic diseases like systemic lupus erythematosus (SLE), mixed connective tissue diseases (MCTD), scleroderma, Sjögren`s syndrome, polymyositis and dermatomyositis.
DANA-Pro is a solid phase enzyme immunoassay for the separate qualitative detection of IgG antibodies against eight cellular and nuclear antigens in human serum. The wells are separately coated with recombinant dsDNA, 70 kDa U1 snRNP, SS-B, SS-A 52 kDa, Scl 70, centromere protein B (CenpB), Jo-1 and highly purified native human Sm and SS-A 60 kDa. The assay is a tool in the differential diagnosis of systemic rheumatic diseases.
Sclero-Pro is a solid phase enzyme immunoassay for the separate qualitative detection of IgG antibodies against eight different cellular and nuclear antigens in human serum. The wells are separately coated with recombinant human 100 kDa PM-Scl, 70 kDa U1-snRNP, SS-B, SS-A 52 kDa, SS-A 60 kDa, Scl 70, centromere protein B (CenpB), Jo-1 and highly purified native human Sm. The assay is a tool in the differential diagnosis of systemic rheumatic diseases.
Nucleo-h is a solid phase enzyme immunoassay with human native nucleosomes isolated from the eukaryotic celline HeLa for the quantitative detection of antibodies against nucleosomes and their components dsDNA and histones in human serum. The assay is a tool in the differential diagnosis of systemic lupus erythematosus (SLE).
dsDNA-Check is a solid phase enzyme immunoassay with human recombinant double-stranded DNA (dsDNA) for the combined quantitative detection of IgG, IgA and IgM antibodies against dsDNA in human serum.The assay is a tool in the differential diagnosis of systemic lupus erythematosus (SLE).
dsDNA-G is a solid phase enzyme immunoassay with human recombinant double-stranded DNA (dsDNA) for the quantitative detection of IgG antibodies against dsDNA in human serum. The assay is a tool in the differential diagnosis of systemic lupus erythematosus (SLE).
ssDNA-Check is a solid phase enzyme immunoassay with human recombinant single-stranded DNA (ssDNA) for the quantitative detection of IgA/G/M antibodies against ssDNA in human serum. Antibodies against ssDNA mainly recognize its basic compound, which is masked inside the helical structure of native DNA. The assay is a tool in the differential diagnosis of systemic lupus erythematosus (SLE).
ssDNA-A is a solid phase enzyme immunoassay with human recombinant single-stranded DNA (ssDNA) for the quantitative detection of IgA antibodies against ssDNA in human serum. Antibodies against ssDNA mainly recognize its basic compound, which is masked inside the helical structure of native DNA. The assay is a tool in the differential diagnosis of systemic lupus erythematosus (SLE).
ssDNA-G is a solid phase enzyme immunoassay with human recombinant single-stranded DNA (ssDNA) for the quantitative detection of IgG antibodies against ssDNA in human serum. Antibodies against ssDNA mainly recognize its basic compound, which is masked inside the helical structure of native DNA. The assay is a tool in the differential diagnosis of systemic lupus erythematosus (SLE).
ssDNA-M is a solid phase enzyme immunoassay with human recombinant single-stranded DNA (ssDNA) for the quantitative detection of IgM antibodies against ssDNA in human serum. Antibodies against ssDNA mainly recognize its basic compound, which is masked inside the helical structure of native DNA. The assay is a tool in the differential diagnosis of systemic lupus erythematosus (SLE).
Histone-C is a solid phase enzyme immunoassay with human native histones H1, H2A, H2B, H3, H4 isolated from the eukaryotic celline HeLa for the quantitative detection of antibodies against histones in human serum. The assay is a tool in the differential diagnosis of systemic lupus erythematosus (SLE).
Rf-Check is a solid phase enzyme immunoassay with highly purified Fc fragment of human immunoglobuline (IgG) for the combined quantitative detection of IgG, IgM and IgA rheumatoid factors (RF) in human serum. The assay is an aid in the diagnosis of rheumatoid arthritis (RA).
Rf-AGM is a solid phase enzyme immunoassay with highly purified Fc fragment of human immunoglobuline (IgG) for the separate quantitative detection of IgG, IgM and IgA rheumatoid factors (RF) in human serum. The assay is an aid in the diagnosis of rheumatoid arthritis (RA).
RA/CP Detect is a solid phase enzyme immunoassay for the quantitative detection of IgG antibodies to specific synthetic citrullinated peptides of human immunoglobulin G (IgG) in human serum. The assay is an aid in the diagnosis of rheumatoid arthritis (RA).
CCP is a solid phase enzyme immunoassay for the quantitative detection of IgG antibodies to specific cyclic citrullinated peptides. The assay is an aid in the diagnosis of rheumatoid arthritis (RA).
Cardiolipin-Check is a solid phase enzyme immunoassay employing highly purified cardiolipin plus native human ß2-glycoprotein I for the combined quantitative detection of IgA, IgG and IgM antibodies against cardiolipin in human serum.
Cardiolipin-GM is a solid phase enzyme immunoassay employing highly purified cardiolipin plus native human ß2-glycoprotein I for the quantitative detection of IgG and /or IgM antibodies against cardiolipin in human serum.
β2-Glyco-GM is a solid phase enzyme immunoassay employing native β2-glycoproteinI highly purified from human plasma for the separate quantitative detection of IgG and / or IgM antibodies against β2-glycoprotein I in human serum. The assay is an aid in the diagnosis and risk of primary and secondary antiphospholipid syndrome (APS).
Serine-GM is a solid phase enzyme immunoassay with highly purified phosphatidyl-serine plus native human ß2-glycoprotein I for the quantitative detection of IgG and/ or IgM antibodies against phosphatidyl-serine in human serum. The assay is an aid in the diagnosis and risk estimation of thrombosis in patients with systemic lupus erythematosus.
Inositol-GM is a solid phase enzyme immunoassay with highly purified phosphatidyl-inositol plus native human beta2-glycoprotein I for the quantitative detection of IgG and/ or IgM antibodies against phosphatidyl-inositol in human serum. The assay is an aid in the diagnosis and risk estimation of thrombosis in patients with systemic lupus erythematosus and APS.
Ethanolamin-GM is a solid phase enzyme immunoassay with highly purified phosphatidyl-ethanolamin plus native human ß2-glycoprotein I for the quantitative detection of IgG and/or IgM antibodies against phosphatidyl-ethanolamin in human serum. These antibodies recognize specific epitopes on a complex composed out of phosphatidyl-ethanolamin and ß2-glycoprotein I. The assay is an aid in the diagnosis and risk estimation of thrombosis in patients with systemic lupus erythematosus and APS.
Cholin-GM is a solid phase enzyme immunoassay with highly purified phosphatidyl-cholin and native human ß2-glycoprotein I for the quantitative detection of IgG and/or IgM antibodies against phosphatidyl-cholin in human serum. These antibodies recognize specific epitopes on a complex composed out of phosphatidyl-cholin and ß2-glyco-protein I. The assay is an aid in the diagnosis and risk estimation of thrombosis in patients with systemic lupus erythematosus (SLE) and the antiphospholipid syndrome (APS).
β2-Glyco-Check is a solid phase enzyme immunoassay employing native β2-glycoproteinI highly purified from human plasma for the combined quantitative detection of IgA, IgG and IgM antibodies against β2-glycoprotein I in human serum. Anti-β2-glycoprotein I antibodies recognize specific epitopes on human β2-glycoprotein I which are expressed only when β2-glycoprotein I interacts with lipid membranes or when absorbed to other surfaces (e.g. microtiter plate). The assay is an aid in the diagnosis and risk of primary and secondary antiphospholipid syndrome (APS).
Phospholipid-Screen is a solid phase enzyme immunoassay for the combined qualitative detection of IgG and IgM antibodies against phospholipids in human serum. Each well is coated with highly purified human ß2-Glycoprotein I, Cardiolipin and Phosphatidyl- cholin, - ethanolamin, -inositol, -serine and Sphingomyelin. The assay is an aid in the diagnosis and risk estimation of thrombosis in patients with systemic lupus erythematosus.
Serin-Prothrombin-Check is a solid phase enzyme immunoassay with highly purified phosphatidyl-serine plus native human prothrombin for the combined quantitative and qualitative detection of IgG and IgM antibodies against phosphatidyl-serine and prothrombin in human serum. The assay is an aid in the diagnosis and risk estimation of thrombosis in patients with systemic lupus erythematosus and anti-phospholipid syndrome (APS).
Phospholipid-Screen-GM is a solid phase enzyme immunoassay for the separate quantitative detection of IgG and/or IgM antibodies against phospholipids in human serum. Each well is coated with highly purified bovine cardiolipin + ß2-glycoprotein I, phosphatidyl- serine, -inositol, - ethanolamin, - choline and sphingomyelin. The assay is an aid in the diagnosis and risk estimation of thrombosis in patients with systemic lupus erythematosus and antiphospholipid syndrome (APS).
Thrombin-Check is a solid phase enzyme immunoassay employing native human thrombin for the combined quantitative detection of IgG, IgA and IgM antibodies against thrombin in human serum. The assay is a tool in the diagnosis of the anti-phospholipid syndrome (APS).
Serine-Prothrombin-GM is a solid phase enzyme immunoassay with highly purified phosphatidyl-serine plus native human prothrombin for the quantitative detection of IgG and/or IgM antibodies against phosphatidyl-serine and prothrombin in human serum. The assay is an aid in the diagnosis and risk estimation of thrombosis in patients with systemic lupus erythematosus and anti-phospholipid syndrome (APS).
Prothrombin-GM is a solid phase enzyme immunoassay employing native human prothrombin (Factor II) for the quantitative detection of IgG and/or IgM antibodies against prothrombin in human serum. The assay is a tool in the diagnosis of the antiphospholipid syndrome.
Annexin V-GM is a solid phase enzyme immunoassay for the quantitative detection of IgG and/or IgM antibodies against Annexin V in human serum. The assay employs native human Annexin V. The assay is a tool in the diagnosis of the antiphospholipid syndrome.
ANCA Pro is a solid phase enzyme immunoassay employing highly purified native myeloperoxidase (MPO) and proteinase 3 (PR3) from human peripheral blood polymorphnuclear cells and native human Cathepsin G, Elastase, Lactoferrin, Lysozym and BPI (bacterial permeability-increasing protein) for the separate semi-quantitative and qualitative detection of antibodies against these antigens in human serum. The assay is a tool in the diagnosis of autoimmune systemic vasculitis.
PR3 sensitive is a solid phase enzyme immunoassay employing highly purified native human proteinase 3 (PR3) from human neutrophil granulocytes for the quantitative detection of antibodies against proteinase 3 in human serum. Anti-PR3 antibodies recognize specificially conformational epitopes only accessible on native PR3. The assay is an aid in the differential diagnosis of autoimmune vasculitis
MPO is a solid phase enzyme immunoassay employing highly purified native myeloperoxidase (MPO) from human peripheral blood polymorphnuclear cells for the quantitative detection of antibodies against MPO in human serum. Anti-MPO antibodies recognize specific conformational epitopes only accessible on native MPO. The assay is a tool in the differential diagnosis of autoimmune systemic vasculitis.
BPI is a solid phase enzyme immunoassay employing highly purified native human BPI (bactericidal/permeability-increasing protein) for the quantitative detection of antibodies against BPI in human serum. Antibodies against BPI can be found in chronically infectious intestinal diseases such as Morbus Crohn or ulcerative colitis.
Elastase is a solid phase enzyme immunoassay employing native human Elastase for the quantitative detection of antibodies against Elastase in human serum. The assay is a tool in the diagnosis of autoimmune systemic vasculitis.
Lactoferrin is a solid phase enzyme immunoassay with human native nucleosomes isolated from the eukaryotic celline HeLa for the quantitative detection of antibodies against nucleosomes and their components dsDNA and histones in human serum. The assay is a tool in the differential diagnosis of systemic lupus erythematosus (SLE).
GBM is a solid phase enzyme immunoassay employing recombinant human glomerular basement membrane protein (GBM) for the quantitative detection of IgG antibodies against GBM in human serum. The assay is an aid in the diagnosis of Goodpasture syndrome.
Vasculitis-Screen is a solid phase enzyme immunoassay for the combined quantitative detection of antibodies against PR3 and MPO in human serum. Each well is coated with native human proteinase 3 (PR3) plus native myeloperoxidase (MPO), both highly purified from human peripheral blood polymorphnuclear cells. Anti-PR3 and anti-MPO antibodies recognize specificially conformational epitopes only accessible on the native target antigen. The assay is an aid in the differential diagnosis of autoimmune vasculitis.
Glia-A is a solid phase enzyme immunoassay employing highly purified alpha-Gliadin for the quantitative detection of IgA antibodies against gliadin in human serum. The assay is a tool in the diagnosis of celiac disease (gluten-sensitive enteropathy).
Glia-G is a solid phase enzyme immunoassay employing highly purified alpha-Gliadin for the quantitative detection of IgG antibodies against Gliadin in human serum. The assay is a tool in the diagnosis of celiac disease (gluten-sensitive enteropathy).
The tTg-A New generation is a solid phase enzyme immunoassay for the quantitative detection of IgA antibodies against neo-epitopes of tissue transglutaminase (tTG) in human serum. The assay employing human recombinant transglutaminase crosslinked with gliadin-specific peptides displays neo-epitopes of tTg which ensures a significantly increased sensitivity and specificity of the test. The assay is a tool for the diagnosis and monitoring of celiac disease (gluten-sensitive enteropathy).
The tTg-G New Generation is a solid phase enzyme immunoassay for the quantitative detection of IgG antibodies against neo-epitopes of tissue transglutaminase (tTG) in human serum. The assay employing human recombinant transglutaminase crosslinked with gliadin-specific peptides displays neo-epitopes of tTg which ensures a significantly increased sensitivity and specificity of the test. The assay is a tool for the diagnosis and monitoring of celiac disease (gluten-sensitive enteropathy).
ASCA-A is a solid phase enzyme immunoassay (ELISA) employing highly purified mannan for the quantitative detection of IgA anti-Saccharomyces cerevisiae antibodies (ASCA) in human serum. ASCA recognize specifically mannan, a component of the outer cell wall of yeast. The assay is highly specific and sensitive for Crohn`s disease.
ASCA-G is a solid phase enzyme immunoassay (ELISA) employing highly purified mannan for the quantitative detection of IgG anti-Saccharomyces cerevisiae antibodies (ASCA) in human serum. ASCA recognize specific mannan, a component of the outer cell wall of yeast. The assay is highly specific and sensitive for Crohn`s disease.
Crohn`s-Check is a solid phase enzyme immunoassay (ELISA) employing highly purified mannan for the combined quantitative detection of anti-Saccharomyces cerevisiae IgA and IgG antibodies (ASCA) in human serum. ASCA recognize specific mannan, a component of the outer cell wall of yeast. The assay is highly specific and sensitive for Crohn`s disease.
CeliCheck New Generation is a solid phase enzyme immunoassay for the combined quantitative detection of IgA and IgG antibodies against neo-epitopes of tissue transglutaminase (tTG) in human serum. The assay employing human recombinant tTG crosslinked with gliadin-specific peptides displays neo-epitopes of tTg which ensures a significantly increased sensitivity and specificity of the test. The assay is a tool for the diagnosis and monitoring of celiac disease (gluten-sensitive enteropathy).
Parietal cell is a solid phase enzyme immunoassay employing purified native H+ /K+ – ATPase for the quantitative detection of antibodies against parietal cells in human serum. Antibodies against parietal cells can be found in pernicious anemia.
Intrinsic factor is a solid phase enzyme immunoassay with recombinant human intrinsic factor for the quantitative detection of IgG antibodies against intrinsic factor. The assay is a tool in the diagnosis of pernicious anaemia (Biermer`s anaemia)
DGP-A is a solid phase enzyme immunoassay employing synthetic, deamidated gliadin-derived peptides for the quantitative detection of IgA antibodies against deamidated Gliadin-specific peptides (DGP) in human serum. The assay is a tool in the diagnosis of celiac disease (gluten-sensitive enteropathy).
DGP-G is a solid phase enzyme immunoassay employing synthetic, deamidated gliadin-derived peptides for the quantitative detection of IgG antibodies against deamidated Gliadin-specific peptides (DGP) in human serum. The assay is a tool in the diagnosis of celiac disease (gluten-sensitive enteropathy).
DGP-Check is a solid phase enzyme immunoassay employing synthetic, deamidated gliadin-derived peptides for the combined quantitative detection of IgA and IgG antibodies against deamidated Gliadin-specific peptides (DGP) in human serum. The assay is a tool in the diagnosis of celiac disease (gluten-sensitive enteropathy).
Calprest® NG quantitative detection of human calprotectin in faecal extracts
ELISA 96 T
Calprest®NG is a quantitative ELISA assay for detecting concentration of fecal calprotectin. Calprest®NGcan be used as an in vitro diagnostic to aid in the diagnosis of Inflammatory Bowel Diseases (IBD, Crohn’s disease and ulcerative colitis) and to differentiate IBD from Irritable Bowel Syndrome (IBS) in conjunction with other clinical and laboratory findings.
LC-1 is a solid phase enzyme immunoassay employing human recombinant formiminotransferase-cyclodeaminase (cytosolic liver antigen) for the quantitative detection of anti-liver cytosol type 1 autoantibodies (anti-LC-1) in human serum. The assay is a tool for the diagnosis of autoimmune hepatitis (AIH).
LKM-1 is a solid phase enzyme immunoassay employing human recombinant cytochrome p450 IID6 for the quantitative detection of antibodies against liver-kidney microsomes (LKM) in human serum.
SLA/LP is a solid phase enzyme immunoassay employing human recombinant SLA/LP for the quantitative detection of IgG antibodies against soluble liver antigen (SLA) in human serum. The assay is a tool for the diagnosis of autoimmune hepatitis (AIH).
AMA-M2-G is a solid phase enzyme immunoassay employing native mitochondial M2 antigen for the quantitative detection of IgG antibodies against M2 in human serum. The assay is a tool in the diagnosis of the primary biliary cirrhosis (PBC).
AMA-M2-M is a solid phase enzyme immunoassay employing native mitochondial M2 antigen for the quantitative detection of IgM antibodies against M2 in human serum. The assay is a tool in the diagnosis of the primary biliary cirrhosis (PBC).
AMA-M2-Check is a solid phase enzyme immunoassay employing native mitochondial M2 antigen for the quantitative detection of IgG and IgM antibodies against M2 in human serum. The assay is a tool in the diagnosis of the primary biliary cirrhosis (PBC).
