Description

. Form liquid
. Alternative Name PWD, WC1, WD, WND
. Purification Immunogen affinity purified
. Purity 95% as determined by SDS-PAGE
. Host Rabbit
. Isotype IgG
. Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
. Background/ FUNCTION
. This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD).
. Immunogen ATP7B
. Specificity Human
. Tested Application IHC
. Recommended dilution IHC: 1:50 – 1:200
. IHC use Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using PAab09904( ATP7B antibody) at dilution of 1:100
. WB use
. Protein Information
. Gene ID 540
. Uniprot ID P35670
. Calculated MW 30 kDa
. Research Area Metabolism, Signal Transduction